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Kris Kasireddy, Ph.D.
Dr. Krishnudu Kasireddy, Ph.D. (Kris Kasireddy) the founder and President of DSK BIOPHARMA INC, R&D from May 2014. Dr. Kasireddy is an accomplished scientist with more than 20 years of experience in organic and medicinal chemistry. Dr. Kasireddy was founder and Vice-president of HDH Pharma from January 2008 to April 2014. Dr. Kasireddy contributed to the development of sRNA based drug delivery technologies during his employment at NeoPharm and achieved employee of the year award in 2005. Dr. Kasireddy has a proven track record of success in delivering the projects in medicinal chemistry and custom synthesis. Before his employment at NeoPharm, he was a postdoctoral fellow at University of Arizona and University of North Texas. Dr. Kasireddy received his PhD in organic chemistry from Indian Institute of Chemical Technology, Hyderabad, India. Dr. Kasireddy, to his credit published more than 30 publications and patents in international journals.
Highlights
- President at DSK BIOPHARMA Inc from May 2014 to till date
- Vice-President at HDH PHARMA Inc from Jan 2008 to April 2014
- Recipient of "employee of the Year" award for 2004
- Co-authored in 22 scientific articles and patents.
- Commercialized two products: Designed and synthesized a cationic analogue of cardiolipin, namely, NeoPhectinTM and NeoPhectin ATTM for the Organization
- Contributed to process development and GMP manufacturing of cationic Cardiolipin
- Developed and directed rationale, strategy and execution of projects in drug discovery
- Identified patentable inventions, co-authored or authored in invention disclosures and patents
- Expertise skills in multi step synthesis and parallel synthesis techniques
- Familiar with structure-based drug design, lead identification and optimization process.
- Expertise in analytical techniques, method development and structural elucidation.
- Familiarity with GLP and GMP regulations.
Professional Experience
- DSK Biopharma, Inc.
- President
- May2014 to till date
- Founder and President at DSK BIOPHARMA, Inc.
- Working with pharmaceutical, biotech companies, research organizations and university labs worldwide to meet the demands and supply innovative compounds for research use.
- Extensive experience with synthesis of new building blocks and Inhibitors.
- Experienced in diverse chemistry of Purines, Pyrimidines, Pyrazoles, Pyrazolopyrimidines, Isoxazoles, Oxadiazoles, Indoles, Oxyindoles, Pyrazines, Piperazines, Amino Acids and Biochemicals (Inhibitors)
- HDH Pharma, Inc.
- Vice-President
- Jan2008 - Apr 2014
- Co-founder and Vice-President of HDH Pharma, Inc from Jan 2008 to April 2014
- Synthesized complex bio-molecules by optimizing the synthesis route using extensive knowledge in organic synthesis.
- Provided synthesis routes for complex molecules (i.e. few thousand building blocks and five hundred plus bio-molecules (Inhibitors))
- Extensive experience with synthesis of new building blocks and Inhibitors
- Experienced in diverse chemistry of Purines, Pyrimidines, Pyrazoles, Pyrazolopyrimidines, Isoxazoles, Oxadiazoles, Indoles, Oxyindoles, Pyrazines, Piperazines, Amino Acids and Biochemicals (Inhibitors).
- Bio-Vin Research Labs
- Senior Scientist
- Aug 2006- Jan 2008
- Extensive experience with synthesis of new building blocks
- Experienced in diverse chemistry of Purines, Pyrimidines, Pyrazoles, Pyrazolopyrimidines, Isoxazoles, Oxadiazoles, Indoles, Oxyindoles, Pyrazines, Piperazines and Biochemicals (Inhibitors)
- Chem Pharm Int'l
- Senior Chemist
- Aug 2005- June 2006
- Designed and successfully synthesized several compounds for treatments to be used after exposure of dirty bombs in collaboration with CPST, University of Kentucky, Lexington.
- Successful in contract research and highly productive in syntheses of compounds for pharmaceutical interest
- Experienced in diverse chemistry of Boronic acids, Amino Acids and Unnatural Amino Acids
- Designed and synthesized various scaffolds, templates and intermediates (1-500g).
- NeoPharm Inc
- Scientist
- Nov 2001-June 2005
- Designed and synthesized various cationic cardiolipin analogues (cationic lipids), which have a potential use in the delivery of DNA, mRNA, siRNA, and a multitude of therapeutic drugs.
- Developed process for cationic cardiolipin and transferred the technology to a contract manufacturing facility for cGMP production
- Successfully translated the laboratory work into two commercial products, NeoPhectinTM and NeoPhectinATTM
- Designed lead molecules and synthesized sugar-based phosphotidylcholine ether lipid analogs as anticancer drugs.
- Synthesized phospholipids (cardiolipin) for internal use in drug formulation development of several anticancer drugs, such as, paclitaxel, docetaxel, SN-38, mitoxantrone and antisense nucleotides
- Univ. of Arizona, Tucson
- Research Associate
- Nov 1999-Nov 2001
- Designed and synthesized novel photoclevable PEGylated cationic lipids and PEGylated phospholipids to impart 'longer circulation' and triggered release of entrapped cancer drugs in drug carriers.
- Designed and synthesized several drug conjugates, such as gemcitabine and cytarabine.
- Gained workable knowledge in liposome preparation and characterization.
- Synthesized florescent water-soluble sulfonatoalkoxy substituted poly (p-phenylene) polymers.
- Univ. of North Texas, Denton
- Research Associate
- Nov 1998- Nov 1999
- Synthesized cage-functionalzed macrocycles such as chiral, aza, fluorinated crown ethers, cryptands, and molecular clefts, which are useful in the study of inclusion phenomena and molecular recognition.
- Design and synthesized high energetic cage compounds that were used in the United States of America Military and Defense fields.
- Indian Institute of Chemical Technology
- Research Fellow
- Dec 1993-Nov1998
- Designed first ever-synthetic pathway to synthesize natural products, Discosiolide, Sporothriolide and 4-epi-Ethisolide, which possess fungicidal, algicidal, antibacterial and herbicidal activities.
- Developed a novel synthetic methodology to make furo [2,3-b] furan system and utilized this methodology to synthesis of (-)- Canadensolide
- Synthesized highly funtionalized chiral spiroacetals, C-C linked disaccharides and C-glycosides
- Developed a new process for the multi-gram synthesis of 4-fluoro salicylic acid and 2-deoxy glucose
Education
- PhD in Organic Chemistry
- IICT, Hyderabad, India
- 1993 - 1998
- Title is 'cationic cardiolipin analogues and use thereof' 2004, PCT/WO/04/ 35523.
- Title is 'cationic cardiolipin analogues and use thereof' 2003, PCT/US/03/ 33099
- Synthesis of short and long chain cardiolipins: Tetrahedron, 2006, 699-6997.
- Synthesis of Cationic Cardiolipin Analogues: Bioorg Chem. 43, 2005, 345-62.
- Synthesis of Novel Cationic Cardiolipin Analogues for the Optimal Delivery of Therapeutic Agents: Tetrahedron Lett. 45, 2004, 2741-2744.
- Synthesis of pseudo saccharide precursors through 'off template site' Michael-Wittig reaction on sugar derived enal. Arkat Organic Journal, 2004, 12-26.
- Synthesis of Novel, Cage-Annulated Fluoromacrocycles: Arkat Organic Journal, 2002, 80-89.
- Novel Approach to Sodium Hydroxide Separation: Synergistic Pseudo-Hydroxide Extraction by a Fluorinated Alcohol and Cage-Functionalized Crown Ethers: J. Am. Chem. Soc. 2001, 123(48), 12099-12100.
- Synthesis of Novel Chiral, Cage-Annulated Macrocycles: Arkat Organic Journal, 2001, 13-21.
- Noval Cage-Annulated Crown Ethers, Cryptands, and Molecular Boxes, Kem. Ind., 2001, 50(3), 129-138.
- Use of Cage-Functionalized Macrocycles and Fluorinated Alcohols in the Liquid-Liquid Extraction of NaOH and Other Sodium Salts: Strategies Toward Waste-Volume Reduction, First accomplishments of the environmental management science program, ACS Symposium Series, 2001, (778), 114-132.
- " Steroselective Synthesis of Highly Oxygenated Cyclohexanes Through a [3+3] Annulation Approach", Tetrahedron Asymmetry, 10, 2000, 4499-4507.
- 'Off Template Site' [3+3] Annulation Reaction on Sugar Derived Enal: Stereoselective Synthesis of C-C Linked Pseudo-Saccharide Precursors. Tetrahedron Asymmetry 2000, 11(13), 2643-2646.
- Radical Medicated Stereoselective Synthesis of Spiroacetals from Enol Ester, Tetrahedron Lett. 41, 2000, 1997-2000.
- Radical Cyclisation Approach for the First Synthesis and Determination of Absolute Stereochemistry of Discosiolide from Diacetone Glucose, Tetrahedron Asymmetry, 1999, 869-85.
- Experimental and Theoretical Investigations into the Stereoselectivity of Epoxidation of Substituted Norbornenes and Norbornadienes, Tetrahedron, 55 1999, 8313-8322.
- Pd(OAc)2 Mediated Oxidative Cyclization of ?,?-Olefinic Alcohols: A New Route to C-Vinyl Furanosides, Tetrahedron Lett., 39, 1998, 6957-6960.
- A Simple and Efficient PdCl2 Mediated Conversion of ?,?-Olefinic Alcohols in C-Glycosides, Tetrahedron Lett., 38, 1997, 9051�9054.
- Pd(II)Cl2 Mediated Oxidative Cyclization of Some 3-Hydroxy-4-vinyl Furanoside Derivatives to Synthetically Valuable Bis-Furanosides, Tetrahedron Lett., 37, 1996, 6007-6011.
- Radical Reactions on Furanoside Acetals: First Synthesis of Sporthriolide and 4-epi Ethisolide from 'Diacetone Glucose', Tetrahedron Lett., 36, 1995, 2661�2664.
- Radical Reactions on Carbohydrate Acetals: Use of a Furanoid Glycal for the Synthesis of cis Fused Bicylic Acetals, Carbohydr. Res., 268, 1995, 287�293.
- Radical Reactions on Furanoside Acetals: A Formal Synthesis of (-)- Canadensolide from D-Mannose, Tetrahedron Asymmetry, 6, 1995, 543-548.